INPP5D and breast cancer: We found that SHIP−/− mice orthotopically implanted with non-metastatic 67NR mammary tumors exhibited only a minor change in phenotype; the presence of 67NR tumors did not alter the number of total cells (Fig. 2A) or myeloid cells (Fig. 1F, 2C) in the lungs, Mφ phenotype (Fig. 1G, 2E), or mouse weight (Fig. 2G), but did cause modest splenomegaly (Fig. 2B) and induced the development of immunosuppressive MDSCs (Fig. 2F).