It is interesting to note that 67NR tumors induced accumulation of immunosuppressive Mφs in the lungs of WT mice (Fig. 1F, 2C), and that these pulmonary Mφs are further elevated in SHIP−/− mice (Fig. 2C), even though 67NR tumors are unable to disseminate from the primary tumor and, therefore, are not metastatic. Here, INPP5D is linked to neoplasm.