INPP5D and neoplasm: While WT spleens showed moderate myeloid, erythroid and megakaryocytic hyperplasia and normal organization 15 days after 4T1 tumor implantation (Supplemental Fig. 4A), the hematopoiesis observed in SHIP−/− spleens was overwhelmingly myeloid in nature and was accompanied by a loss of typical architecture (Supplemental Fig. 4B), suggesting deregulation of myelopoiesis in the absence of SHIP.