INPP5D and neoplasm: As shown in Fig. 2A, orthotopic 67NR tumors increased lung cellularity in WT mice and induced modest splenomegaly in both WT and SHIP−/− BALB/c mice (Fig. 2B), although the relative differences were comparable between 67NR-bearing and naïve (tumor-free) WT and SHIP−/− mice.