Although there was no difference in absolute spleen weight measured 15 days after tumor implantation (Supplemental Figure 2B), SHIP−/− mice had a much higher splenic index (ratio of spleen weight to body weight) compared to WT mice (Fig. 3B), due to the extreme weight loss observed in the SHIP−/− BALB/c mice. Here, INPP5D is linked to neoplasm.