INPP5D and neoplasm: We also performed sensitive clonogenic assays on cells isolated from the lungs of tumor-bearing mice and found that the lungs of SHIP−/− mice possessed a higher proportion of clonogenic cells (Fig. 5D) that translated into 7.5-fold more metastatic tumor cells (Fig. 5E) than the lungs of WT mice 15 days after primary tumor implantation.