INPP5D and neoplasm: As well, it is noteworthy that SHIP deficiency preferentially increases the levels of M-MDSCs and Mφs (Fig. 3E, Supplemental Fig. 3C), since M-MDSCs are more immunosuppressive than G-MDSCs [50–52] and our previous work shows that Mφs are up to 30-fold more potent suppressors of activated T cell proliferation than MDSCs in tumor-bearing WT BALB/c mice [29].