Above all, MM patients bearing high MTDH expression suffered poor clinical outcomes relative to low-MTDH-expressing patients in TT2 (Total Therapy 2) cohort and as shown in Figure 1E and 1F elevated MTDH expression is linked to significantly shorter response duration of both event free (EF) and overall survival (OS) respectively. This evidence concerns the gene MTDH and Miyoshi myopathy.