To further validate the role of MTDH in MM, we knocked down MTDH expression in MM cell lines using lentiviral shRNA and the results showed that decreased MTDH induced MM cellular growth inhibition (Figure 2C), clonogenicity reduction (Figure 2D), apoptosis in vitro (Figure 2E & 2F) and tumorigenicity suppression in vivo (Figure 3). The gene discussed is MTDH; the disease is Miyoshi myopathy.