To better recognize the molecular basis of MM, Shaughnessy JD Jr et al. categorized MM patients into 8 subgroups based on Gene expression profiling (GEP), including CD1 and CD2 subgroup with CCND1 and CCND3 translocation, hyperdiploidy (HY) group, myeloid-like group (MY), low bone disease (LB) group, MMSET/FGGR3 spike group (MS), MAF/MAFB (MF) spike group and proliferation (PR) group [5, 6]. Here, CD2 is linked to Miyoshi myopathy.