A positive interactive effect of HE treatment on the levels of TNFα (Finteraction (1, 16) = 12.34, p = 0.0029), IL-1β (Finteraction (1, 16) = 11.58, p = 0.0036), and IL6 (Finteraction (1, 16) = 31.06, p < 0.0001) was confirmed by two-way ANOVA. The gene discussed is IL1B; the disease is hereditary elliptocytosis.