Consistent with our results, IFN-γ deficiency was generally observed in PBMCs at basal level or upon stimulation by other ligands including lipopolysaccharide (LPS), Staphylococcal enterotoxin B (SEB), house dust mite (HDM), Candida albicans (CA) and phytohaemagglutinin (PHA) in AD patients [17–19]. Here, IFNG is linked to Alzheimer disease.