The distribution of TACC3 at the interface of the mitotic spindle-assembling machinery, vital for tumor survival and progression, makes TACC3 a superior therapeutic target for anti-cancer drugs precisely designed to inhibit the mitotic spindle-microtubule of cancer with aberrant TACC3, without interfering with the microtubules activity in non-dividing cell. The gene discussed is TACC3; the disease is neoplasm.