CALR and melanoma: Using a bona fide ICD inducer, Hypericin-based PDT (Hyp-PDT) [6], we found that human melanoma cell-associated macroautophagy suppresses exposure of ecto-CRT (possibly by reducing oxidative-ER stress), which in turn reduces maturation of the interacting DCs, DC-derived IL6 production and proliferation of IFN-γ producing CD4+/CD8+ T cells (Figure 1) [6].