TGFB1 and neoplasm: Recent work from our lab has built upon these findings by demonstrating that the inhibin βA transcript is translationally regulated by hnRNP E1 during TGFβ-induced EMT, and the consequent establishment of Activin A autocrine and paracrine signaling is capable of altering the tumor microenvironment and promoting a permissive niche at both the primary tumor site and at secondary metastatic foci [7].