We recently identified miR-219-1-3p as a new negative regulator of MUC4 mucin expression in pancreatic cancer (PC) cells and showed a converse correlation in human pancreatic adenocarcinomatous tissues and in the early steps of pancreatic carcinogenesis (PanINs) in the preclinical Pdx1-Cre; LstopL-KrasG12D transgenic mouse model [7]. Here, MUC4 is linked to familial pancreatic carcinoma.