Participants with a higher level of ApoA1 might have a lower risk of cognitive impairment, indicating that ApoA1 might be a protective factor in the process of cognitive impairment; on the contrary, ApoA2 might be an adverse factor of cognitive performance; that is, participants with a higher level of ApoA2 had a higher risk of undergoing cognitive impairment. Here, APOA2 is linked to Cognitive impairment.