We evaluated 32 factors which were known or unknown to be risks for cognitive impairment and found out that age, levels of fundus AS, POD, IL-6, HDL-C, ApoA2, and ApoC2 were significantly changed among different cognitive statuses, and ApoA1 and ApoA2 might be independently associated with cognitive impairment after adjusting for age, BMI, levels of fundus AS, and comorbidities. This evidence concerns the gene APOA2 and Cognitive impairment.