Omentin-1 plays a potential role in lipid metabolism and insulin sensitivity thus, when omentin-1 decreased leading to insulin resistance and hyperinsulinemia which per se encourage hepatic triglyceride (TG) synthesis which blocks conversion of very low density lipoprotein (VLDL) into high density lipoprotein (HDL), this leads to high VLDL and low HDL which are concerned with progression of atherosclerosis and IHD; thus, omentin-1 is a protective factor in IHD [18, 19]. Here, INS is linked to Insulin resistance.