PRRT2 and diabetes mellitus: Moreover, metformin was reported to prevent hyperglycemia induced cardiovascular damage through oxidative stress pathway since chronic hyperglycemia in DM activates protein kinase C (PKC) which leads to increases in the endothelial permeability, neutrophil activation, and cytokine stimulation, with all of these leading to vascular and cardiac complications of DM, therefore, metformin, leading to significant cardiovascular protection in diabetic patients through modulation of PKC [30, 31].