TLR7 and asthma: Some investigators have reported that genetic variations in TLR7 and reduced TLR7 expression and function are associated with asthma,35, 36, 37, 38 Given that TLR7 is most strongly expressed in pDCs and our current finding that the pDCs are the primary cell responsible for RV16-stimulated IFN production will be important for future studies of antiviral immunity in asthma to focus on pDC and TLR7.