Trx are involved in multiple redox-dependent signaling pathways in cancer by regulating redox-sensitive transcription factors (e.g., activator protein 1 (AP-1), NF-κB, and p53); signaling proteins (e.g., protein tyrosine phosphatases, PTPs, and PTEN); and other antioxidant proteins involved in the regulation of these signaling cascades (e.g., peroxiredoxins). Here, PTEN is linked to cancer.