The aim of the current study was to evaluate the possible relation of NOS3 G894T genotypes with the levels various protein and lipid oxidation markers and antioxidant status such as PCO, AOPP, LHP, total thiol protein thiol, nonprotein thiol, and Cu, Zn-superoxide dismutase (Cu, Zn-SOD) in patients with LC. The gene discussed is SOD1; the disease is laryngotracheoesophageal cleft.