MAPK8 and cancer: Compared to the control, JC had no obvious effect on the nuclear translocation of p65 and the phosphorylated level of p38, JNK, and ERK; however, the level of Akt phosphorylation on Ser473, which has been shown to be an important driver of human cancer [25], was greatly increased (Figures 2(a)–2(d) and 2(g)).