NFE2L2 and familial pancreatic carcinoma: To explore the possible roles of Nrf2 pathway and autophagy under oxidative stress in pancreatic cancer cell lines, we first detected the expression of Nrf2 in 5 pancreatic cancer cell lines (BxPc-3, PANC-1, SW1990, AsPC-1, and MiaPaCa-2) by Western blot and real-time PCR analyses, respectively (Figures 1(a)-1(b)).