In addition to brusatol, natural compounds such as chrysin, apigenin, luteolin, and trigonelline are known to inhibit NRF2 signaling in several types of cancer cells [102, 168–170] and therefore the development of NRF2 inhibitors with characterized modes of action will enable efficient targeting of the redox homeostasis system as well as multidrug resistance systems in CSCs. Here, NFE2L2 is linked to cancer.