We have also observed that AFB1 intoxication implicates alterations in the antioxidant enzymes and proinflammatory cytokines to develop HCC in rats [15] and that Fisetin treatment is able to normalize the level of GST-pi (glutathione-S-transferase, placental type), a HCC marker, and to regress HCC lesions in those HCC livers (data of the present report). The gene discussed is HPGDS; the disease is hepatocellular carcinoma.