AFP and neoplasm: Multivariate analyses revealed that the following factors had significant effects on OS: AFP normalization (hazard ratio [HR] = 0.31; 95 % CI, 0.14–0.70; p < 0.005); age (HR = 1.08; 95 % CI, 1.03–1.14; p < 0.004); and tumor size (HR = 1.66; 95 % CI, 1.14–2.40; p < 0.008).