The Lynch syndrome/colorectal cancer panel, containing MLH1, MSH2, MSH6, PMS2, EPCAM, APC, and MUTYH, had the highest yield (13.7% overall, 17.6% among affected individuals), whereas the breast cancer high-risk panel containing BRCA1, BRCA2, CDH1, PTEN, STK11, and TP53 had the lowest yield (3.8% overall, 4.2% among affected individuals). This evidence concerns the gene MLH1 and colorectal cancer.