Twelve women with breast cancer had multiple positive findings: one with findings in two high-risk genes (BRCA2/VHL), seven with a result in one high-risk gene (e.g., BRCA1/PALB2, BRCA2/CHEK2, biallelic MUTYH/CHEK2), and four with positive results in genes of moderate or unknown risk (all CHEK2/ATM or compound heterozygous or homozygous for CHEK2). The gene discussed is VHL; the disease is breast cancer.