Myristoylated alanine-rich C kinase substrate-like 1 (MARCKSL1) is a tumor suppressor that regulates actin cytoskeleton, cell movement, EMT, fibrosis and the invasiveness and metastasis of tumors by suppressing lysyl oxidase-like 2 (LOXL2) and the FAK/Akt/mTOR signaling pathways [68] The down-regulation of MARCKSL1 by chlamydia promote EMT, fibrosis and tumorigenesis. The gene discussed is PTK2; the disease is neoplasm.