Add1 is a component of adducin (ADD), a heterodimeric actin-binding cytoskeleton protein consisting of an α-subunit with either a beta- or a gamma-subunit where the alpha-subunit (Add1) is known to increase renal sodium reabsorption and therefore considered to be involved in the pathophysiology of essential hypertension [58] possibly through regulation of epithelial sodium channel. The gene discussed is ADD1; the disease is essential hypertension.