In addition, members of miR-29 family control cell invasion by suppressing molecules involved in cell invasion and migration in the focal adhesion signaling pathway, including laminin gamma1 (LAMC1), laminin gamma1 (LAMC2) and alpha6 integrin (ITGA6) [22]; and heat-shock protein-47 (HSP47), a target of miR-29a, is involved in the maturation of collagen molecules, and is upregulated in fibrosis and several cancers especially cervical intraepithelial neoplasia where miR-29a is often down-regulated [23]. This evidence concerns the gene ITGA6 and cancer.