CCNE1 and adenocarcinoma: Cox proportional hazards analysis showed that adenocarcinoma patients with cyclin D1 overexpression were found to have a 1.87 (95 % confidence interval = 1.12 – 2.69, P = 0.02) times poorer RFS than those without (Table 2), after adjusting for age, tumor size, pathologic stage, and cyclin E expression.