The role of CR1 in AD development has been highlighted due to involving in erythrocyte amyloid β42 sequestration and clearance of Aβ from whole blood [25], and the missense variant rs6691117 (Ile→Val) may change the folding of CR1 protein and affect structural stability through affecting Hsp70 binding, then cause functional changes [26]. This evidence concerns the gene CR1 and Alzheimer disease.