On the other hand, seven different functional pathways were found enriched in up-regulated genes, including β-Alanine metabolism, fructose and mannose metabolism, N-glycan biosynthsis, Fanconi anemia pathway, MAPK cascade, p38 MAPK signalling pathway and FAS pathway/Stress induction of HSP regulation (see Figure 3a). The gene discussed is FAS; the disease is Fanconi anemia.