After GO-enrichment analysis, 10 immune system process were found enriched in up-regulated genes, including Adipocytokine signaling pathway, NF-κB signalling pathway, Hepatitis B, TNF signalling pathway, Rap1 signalling pathway, Chemokine signalling pathway, transcriptional mis-regulation in cancer, Cholinergic synapse, osteoclast differentiation and toll-like receptor signalling pathway (see Figure 3b). Here, TNF is linked to cancer.