BAP1 and cancer: In recent years, BRCA1 associated protein 1 (BAP1), a nuclear deubiquitinating enzyme has emerged as an important tumor suppressor protein, undergoes frequent mutations in different types of tumor and appears as one of the driver genes in cancer types like uveal melanoma1, mesothelioma2, renal cell carcinoma3, cholangiocarcinoma4 and melanocytic tumors5.