A translocation of SS18, a member of SWI/SNF complex [47] in the tumor, homozygous frame-shift deletion in the histone acetyltransferase EP300 and a fusion of methyl CpG binding protein MECP2 and F8 in THJ-16T cell line, complete loss of SMARCA2, another member of the SWI/SNF complex and interacting partner of SS18 [47], in THJ-21T, a heterozygous frame-shift deletion in the histone deacetylase HDAC10 and a gene fusion of the transcriptional repressor and member of the SWI/SNF complex BCL11A [47] and GRIP2 in THJ-29T. The gene discussed is F8; the disease is neoplasm.