We predict, based on the current study, that lenvatinib would not result in prolonged response in ATCs given the lower expression of all its targets (vascular endothelial growth factor receptors 1,2, and 3, fibroblast growth factor receptors 1, 2, 3 and 4, platelet-derived growth factor receptor alpha, RET and KIT) in ATC specimens (Additional file 2: Figure 3). This evidence concerns the gene FLT1 and Ehlers-Danlos syndrome, musculocontractural type.