The result indicated that the individuals who have higher values of variables 83, 117, 140, and 180 (RBM_CEA, RBM_IL-13, RBM_Myoglobin and Age), and lower values of variables 21, 106, 111, 123, 172 and 177 (Pathology_K, RBM_HB-EGF, RBM_IgA, RBM_IL-3, Plasma_ApoE and Plasma_Mehta_AB42) have higher risk of getting into MCI/AD within 54 months. Here, APOE is linked to Alzheimer disease.