PRNP and early-onset autosomal dominant Alzheimer disease: The emerging links between microtubule PTM regulation and neurodegeneration42 and evidence that a significant number of signalling pathways altered in Prnp−/− embryos are over-activated at late stage of prion disease pathogenesis14 warrant the study of possible alterations in microtubule dynamics during PrPC-dependent neurodegeneration in prion diseases and Alzheimer’s disease.