CARD9 and candidiasis: Although the extent of neutrophil accumulation may still be to a degree suboptimal relative to the higher kidney fungal load seen in Card9-/- kidneys [22, 24, 32], the data collectively indicate that Card9 plays organ-specific roles in neutrophil accumulation after systemic candidiasis, in agreement with a recent report showing neutrophil mobilization into the C. tropicalis infected Card9-/- kidney [33].