CARD9 and infection: Specifically, Card9-/- mice infected with Aspergillus recruited normal numbers of neutrophils to the lung in the early phase of the infection driven via IL-1R/Myd88–dependent CXC chemokine production, whereas at the later stages of the infection a 40% decrease in neutrophil accumulation was observed, which was due to decreased CXC chemokine production by Card9-/- hematopoietic cells [38, 42].