Since the IL-17/IL-22 pathway has also been shown to promote neutrophil recruitment into infected tissues [34], and some CARD9-deficient patients have reduced Th17 cells in the peripheral blood [7, 9, 13], we determined the levels of IL-17 and IL-22 in the brains of WT and Card9-/- mice following infection. The gene discussed is CARD9; the disease is infection.