IL4 and Increased total eosinophil count: However, cytokine production by in vitro cultured skin biopsies showed that the reduction in eosinophilia following anti‐CCR3 mAb treatment had no effect on the levels of IL‐12p40 and IL‐4 (Fig. 2c,d; P > 0·05), whilst there was a significant increase in IL‐10 only in 1x mice (Fig. 2e; 1x mice, P < 0·05; 4x mice, P > 0·05).