Therefore, as CD4+ hyporesponsiveness in the sdLN of 4x mice in our infection model is IL‐10 dependent 12, and the partial recovery in CD4+ T‐cell responsiveness in the 4x infected Mcpt5Cre iDTR mice was accompanied by a loss in the production of IL‐10, we propose mast cells contribute signals to condition dermal CD4+ T cells in the skin to produce further IL‐10. This evidence concerns the gene CD4 and infection.