CXCR3 and infection: Cxcr3 KO mice, defective in responsiveness to CXCL9 and CXCL10, have delayed granulomatous responses but show otherwise effective antimicrobial function [53]; A similarly delayed response to aerosolized MTB infection was noted in Cxcr3 KO mice, suggesting that neutrophils were important for regulating early inflammation, though ultimately clearance of infection was obtained in these mice [54]; hence, Cxcr3 was not essential for immunity to L. donovani but allowed optimal recruitment of leucocytes to the granuloma [53].