It has been documented that Kv7 channels encoded by KCNQ gene family contributed to vasoconstriction and hypertension [30], which was in concert with the discovery that both C3H/HeJCrl-Kcnq1vtg-2J/J mice [31] and WTC-dfk rats [32] with a KCNQ1 mutation exhibited significantly higher blood pressure. Here, KCNQ1 is linked to Hypertension.