TGFB1 and gastrointestinal disease: IPA identified top functions for this network as “organismal injury and abnormalities,” “gastrointestinal disease,” and “dermatological diseases and conditions.” 29 of the 35 mRNAs in this pathway were up-regulated (6 were not up-regulated), and many of these 29 transcripts had direct interactions with TGF-β1 (Fig 4).