TOP2A and type 2 diabetes mellitus: Of the 10 most highly expressed transcripts exclusive to LOCK, regulation of the cell cycle, type 2 diabetes, adipogenesis and cell proliferation, and inflammation have been associated with topoisomerase II alpha (TOP2A) [39], cyclin-dependent kinase inhibitor 3 (CDKN3) [40], monoclonal antibody Ki-67 (MK167) [41], TPX2, microtubule-associated, homolog (TPX2) [42], cyclin A2 (CCNA2) [43], aurora kinase B (AURKB) [44], and kinesin family member 23 (KIF23) [44].