Moreover, Rho and colleagues found that over-expressedPDCD6 inhibits angiogenesis through the PI3K/mToR/p70S6K pathway byinteracting with VEGFR-2 [66],while Park et al. showed that PDCD6 exerts its anti-tumor potency by activating thep53-p21 protein for G1 phase of cell cycle progression and apoptosis involvedin human ovarian tumorigenesis. This evidence concerns the gene RPS6KB1 and neoplasm.