Cdc2 was similarlydifferentially expressed between L-OHP very sensitive and less sensitive cell lines.CDK1 (which codes for cdc2) loss elicited chemotherapeuticresistance in lung cancer [86],while cdc2 was differentially expressed in a study of responses to L-OHP three CRC celllines [87]. The gene discussed is CDK1; the disease is colorectal carcinoma.