Overall, when the data was pooled, methylation, expression significances were combined and only genes with more than 15% methylation change were selected, best performing results were reached with 12 pathways in top20 functional enrichment results (Table 2, 3, 4, 5) namely; MAPK signalling, Extracellular matrix receptor, ErbB signalling, TGF-beta signalling, Notch signalling, Neurotrophin signalling, Apoptosis, Focal adhesion, Pathways in cancer, Toll-like receptor signalling, Pentose-phospate and Adherens junction pathways. The gene discussed is EGFR; the disease is cancer.