STAT3 and diabetic kidney disease: We found only two instances in which the ChIP-seq binding targets of STAT1, STAT3 or NFκB showed a significant overlap; specifically, NFκB ChIP-seq targets from lymphoblastoid cell lines showed a strong overlap with genes that change expression in diabetic kidney disease and STAT3 ChIP-seq targets from MCF-10 breast cancer cell lines showed an overlap with genes that are differentially regulated upon knockdown of PGC-1α in melanoma cell lines (S2 Table).