To identify the putative cancer-associated nuclear body, we initially stained two human leukemia cell lines KG-1 (acute myeloid leukemia, AML) and MEG-01 (chronic myeloid leukemia, CML) by immunofluorescence staining with antibodies against phosphorylated eIF4E (p-eIF4E) or total eIF4E (t-eIF4E). This evidence concerns the gene EIF4E and cancer.