MAP2K1 and melanoma: Starting from this initial evidence, in this study we assessed responsiveness to BRAFV600E-, MEK1/2-, dual PI3K/mTOR- and dual mTORC1/2-specific inhibitors in 49 BRAF-mutant melanoma cell lines and in an independent set of 23 BRAF-mutant short-term melanoma cell cultures, all isolated from patients never treated with target therapy.