Further assays looking at the generation of active, cleaved caspase-3, indicated that AZD6244-BEZ235 was the most effective treatment, compared to PLX4720-BEZ235 and to AZD6244-AZD8055 in melanoma cells from group 3 (Me71) and from group 1 (Me6, Me13 and Me79, Supplementary Figure 11A, 11B). This evidence concerns the gene CASP3 and melanoma.