Interestingly, in melanoma cells with acquired resistance to BRAF inhibition, Shi et al. [16] found that PLX4720, alone or in combination with BEZ235 or AZD8055, induced early and delayed p-ERK recovery, while AZD6244 in association with BEZ235 or AZD8055, strongly reduced such effect. This evidence concerns the gene BRAF and melanoma.