BCL2 and melanoma: By protein arrays experiments we found that AZD6244-BEZ235 was more effective than PLX4720-BEZ235 at enhancing expression of the Bax protein, a pro-apoptotic Bcl-2 family member, and at downregulating the inhibitor of apoptosis c-IAP1 in melanoma cells from the three groups and of livin/ML-IAP in melanoma cells from group 1 and 2 (Figure 8).