This comparison indicated that AZD6244-BEZ235 induced a selective downmodulation of several genes, including c-FOS (Figure 10A), recently involved in melanoma resistance to MAPK inhibition [13], and p90RSK encoding for proteins that phosphorylate CREB transcription factors [27–28], also involved in melanoma resistance to MAPK inhibition [13]. This evidence concerns the gene CREB1 and melanoma.