AZD6244-BEZ235, but not PLX4720-BEZ235, downmodulated the anti-apoptotic gene Bcl-2 and the mTOR interactor 4EBP1 (Figure 10B), as well as β catenin, a gene that impairs T cell-mediated immune response in melanoma [29], and LEF-1 [30] a β catenin interacting partner (Supplementary Figure 16B, 16C). Here, BCL2 is linked to melanoma.