PECAM1 and neoplasm: Although there was less vascularization in kindlin-3 siRNA tumor based on CD31 western blotting and kindlin-3 siRNA cells expressed and secreted lower level of VEGF-A, we rationalize that the smaller tumor growth of these cells is attributed primarily to the reduced c-Myc protein expression because smaller cell colonies were seen in the soft agar assays that is not dependent on either VEGF or vascularization.