Although there was less vascularization in kindlin-3 siRNA tumor based on CD31 western blotting and kindlin-3 siRNA cells expressed and secreted lower level of VEGF-A, we rationalize that the smaller tumor growth of these cells is attributed primarily to the reduced c-Myc protein expression because smaller cell colonies were seen in the soft agar assays that is not dependent on either VEGF or vascularization. This evidence concerns the gene MYC and neoplasm.