Examples include the association of the APOE/TOMM40 locus with pancreatic cancer and total cholesterol levels, the association of the ABO locus with macular degeneration and coronary artery disease, and the association of the SH2B3/ATXN2 locus with diastolic blood pressure and rheumatoid arthritis. The gene discussed is APOE; the disease is rheumatoid arthritis.