LOX and Alzheimer disease: However, the important role of LOX in the pathomechanism of AD has also been related to the brain cell survival pathway via involvement in the synthesis of antiapoptotic and neuroprotective docosahexaenoic acid (DHA)-derived 10R,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid, known as neuroprotectin D1 (NPD1) (Fig. 7) [129–131].