HMOX1 and malaria: It has been reported that ferritin promotesdisease resistance to malaria by preventing labile intracellular iron from sustainingpro-apoptotic c-Jun N-terminal kinase activation, and this tolerance requires theexpression of HO-1 (Gozzelino et al. 2012).Interestingly, malarial tolerance mediated by ferritin production is independent of theparasitaemia rate and represents a host defence strategy to limit the fitness costs ofinfection irrespective of pathogen burden (Medzhitov etal.