Mechanisms by whichhaemoglobinopathies may attenuate the pathogenesis of malaria caused by P.falciparum include modulation of the inflammatory response and enhancement ofcell-mediated and humoural immune responses through pathways that may include haemeoxygenase-1 (HO-1), reduced levels of cerebral chemokines, increased levels of nitricoxide, and higher IgG seroreactivity to P. falciparum antigens (Taylor et al. 2013). This evidence concerns the gene HMOX1 and malaria.