The superior tumor-cell killing effect of IL-15/IL-15Rα EP DC/NK-cell cocultures leveled out to the cytotoxic level of IL-15 EP DC/NK-cell cocultures using transwells, indicating that a contact-dependent IL-15 transpresentation mechanism is involved in the superior killing effect (Figure 4A, p < 0.001). This evidence concerns the gene IL15RA and neoplasm.