Emerging findings support the function of WWOX as a tumor suppressor: (i) overexpression of WWOX in WWOX-negative cancer cells reduces cell growth and suppresses tumor growth in immunodeficient mice [36–38]; (ii) Wwox-mutant mice showed higher incidence of spontaneous and chemically-induced tumors [39, 40]; (iii) WWOX molecularly regulates several cellular processes implicated in tumor initiation and/or progression [37, 41]. The gene discussed is WWOX; the disease is neoplasm.