When we stained tumor tissues of CD133+, A549IL-6si- and CD133+, A549sc-xenografts with the EMT/metastasis markers, we observed higher numbers of cells positively stained with these markers in tumor tissues of CD133+, A549sc-xenografts than those of CD133+, A549IL-6si-xenografts (Figure 6C). The gene discussed is PROM1; the disease is neoplasm.