In this study, we could show that the combination of erlotinib with PS indeed exerts additive antineoplastic effects upon the EGFR-mutated adenocarcinoma cell line HCC827 and the EGFR wt adenocarcinoma cell line A549, whereas this effect was not seen in the large-cell carcinoma cell line NCI-H460. Here, EGFR is linked to large cell carcinoma.