KRT5 and psoriasis: Of translational importance, recent work done by our group [18] and others (Dr. Nehal Mehta, NHLBI, personal communication) have identified circulating pro-inflammatory monocytes in psoriasis patients that resemble the increased CD11b+Ly6Chigh cells observed in the KC-Tie2 model, and which we hypothesize will also be elevated in K5-IL-17C mice, providing a potential link between chronic skin inflammation and the CVD co-morbidities.