Activation of TLR4/NF-κB signaling in gastric cancer cell lines expressing TLR4 at low and high levels by the TLR4 ligand LPS and DNA methyltransferase inhibitor 5-aza-dC provides a new direction for research on TLR4 signaling in cells silenced by promoter methylation, and promote cell survival and proliferation [56]. This evidence concerns the gene TLR4 and gastric cancer.