Recent evidence suggests involvement of RTKs such as PDGFR [29, 36, 37], c-Met [38], Axl [39], IGF1-R [40], EphB4 [41] and ErbB4 [42] as driver kinases in different sarcoma subtypes including synovial sarcoma, Ewing sarcoma as well as malignant peripheral nerve sheath tumor (MPNST). This evidence concerns the gene AXL and malignant peripheral nerve sheath tumor.