This collaboration is observed in genes regulated by two or more differentially expressed miRNAs, e.g. EEF1A1, related with the progression and transformation of PCa [48], AGO1, related with miRNA mediated gene silencing in cancer [49] and KLF9, a transcriptional factor that inhibits AKT activation and inhibit the PCa cells growth [50]. Here, AKT1 is linked to posterior cortical atrophy.