INS and myocardial infarction: Over the past 30–40 years, a vast number of therapies with proven efficacy for preventing myocardial reperfusion injury and reducing MI size in experimental animal studies (eg, antioxidants, magnesium, calcium-channel blockers, anti-inflammatory agents, erythropoietin, atorvastatin, glucose-insulin-potassium therapy, adenosine) have produced disappointing results when investigated in the clinical setting as adjunctive therapy to reperfusion (reviewed in Ref.